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Cayman Toosendanin
List Price $42.00 Your Price $42.00
Cayman Toosendanin - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART: CAYM-34042-1
MFG.PART: 34042-1
UNSPSC: 12352200
Manufacturer: Cayman
Product Description
Toosendanin is a triterpenoid that has been found in M. toosendan and has diverse biological activities.,, It inhibits the proliferation of BEL-7404, U251, SH-SY5Y, HL-60, PC3, and U937 cancer cells (IC50s = <0.17 µM for all). Toosendanin is larvicidal against A. aegypti first instar larvae (LC50 = 60.8 µg/mL) and delays pupal development when used at concentrations ranging from 6.3 to 25 µg/mL. It decreases serum levels of TNF-α, IL-1β, and IL-6 in a mouse model of ulcerative colitis induced by dextran sulfate (sodium salt) (DSS; Item No. ) when administered at doses of 0.5 and 1 mg/kg. Toosendanin (9 mg/kg) increases survival in a mouse model of botulism induced by botulinum neurotoxin serotype A (BoNT/A).
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
[C(R),1α,3α,4β,
CAS Number
58812-37-6
Synonyms
- Chuanliansu
- 28-Deacetylsendanin
Molecular Formula
C30H38O11
Formula Weight
574.6
Purity
≥95% (mixture of isomers)
Formulation
A solid
Solubility
- DMF: 30 mg/mL
- DMSO: 30 mg/mL
- DMSO:PBS (pH 7.2) (1:6): 0.14 mg/mL
- Ethanol: 5 mg/mL
SMILES
C[C@]12[C@]34[C@]([C@@](C5=COC=C5)([H])C[C@@]3([H])O4)([C@H](C([C@]1([H])[C@]67[C@@]([C@]([C@@H](C[C@@H]6O)OC(C)=O)([C@@H](OC7)O)C)([H])C[C@H]2O)=O)OC(C)=O)C
InChi Code
InChI=1S/C30H38O11/c1-13(31)39-20-10-19(34)29-12-38-25(36)26(20,3)17(29)9-18(33)28(5)23(29)22(35)24(40-14(2)32)27(4)16(15-6-7-37-11-15)8-21-30(27,28)41-21/h6-7,11,16-21,23-25,33-34,36H,8-10,12H2,1-5H3/t16-,17-,18+,19-,20+,21+,23-,24-,25+,26+,27+,28+,29+,30+/m0/s1
InChi Key
NAHTXVIXCMUDLF-RFNFAWMESA-N
Origin
Plant/Melia toosendan
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-34042-1 |
|---|---|
| Supplier Part Number | 34042-1 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | China |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | Y |
| CAS Number | 58812-37-6 |
| Energy Star | No |
| Green | No |
| Controlled | N |