Cayman ATN-161 (trifluoroacetate salt)

ATN-161 is a peptide derived from fibronectin and an integrin αVβ3 and αVβ5 antagonist.¹ It binds to αVβ3 and αVβ5 receptors (K_ds = 0.69 and 1 µM, respectively) in MDA-MB-231 breast cancer cells, as well as inhibits the interaction between αVβ5 and human angiotensin-converting enzyme 2 (ACE2) or severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein in a concentration-dependent manner in cell-free assays.^1,2 ATN-161 reduces viral titers in Vero E6 cells infected with SARS-CoV-2 (EC₅₀ = 3.16 µM).² It inhibits VEGF-induced migration and capillary tube formation of primary human choroidal endothelial cells when used at a concentration of 0.1 µM.³ ATN-161 (1 mg/kg) reduces tumor growth and metastasis in an MDA-MB-231 mouse xenograft model and infarct volume and edema in a mouse model of ischemic stroke induced by middle cerebral artery occlusion (MCAO).^1,4

WARNING This product is not for human or veterinary use.