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Cayman SM-16
List Price $41.00 Your Price $41.00
Cayman SM-16 - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART: CAYM-34061-1
MFG.PART: 34061-1
UNSPSC: 12352200
Manufacturer: Cayman
Product Description
SM-16 is an inhibitor of activin-like kinase 5 (ALK5), also known as the TGF-β type 1 receptor (Ki = 44 nM).1 It is selective for ALK5 over a panel of 60 non-ALK kinases, as well as ALK1 and ALK6, at 10 µM. SM-16 inhibits TGF-β1-induced reporter activity (IC50 = 64 nM) and SMAD2/3 phosphorylation (IC50s = 160-620 nM) in vitro. In vivo, SM-16 (15 and 30 mg/kg) inhibits neointimal formation and luminal narrowing in a rat model of carotid injury. SM-16 (5 mg/kg) inhibits tumor growth in an AB12 murine malignant mesothelioma model.2
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
4-[4-(1,3-
CAS Number
614749-78-9
Molecular Formula
C25H26N4O3
Formula Weight
430.5
Purity
≥98%
Formulation(Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
- DMF: 30 mg/mL
- DMSO: 30 mg/mL
- DMSO:PBS (pH 7.2) (1:5): 0.16 mg/mL
- Ethanol: slightly soluble
SMILES
NC(C12CCC(CC2)(C3=NC(C4=CC=CC(C)=N4)=C(C5=CC=C(OCO6)C6=C5)N3)CC1)=O
InChi Code
InChI=1S/C25H26N4O3/c1-15-3-2-4-17(27-15)21-20(16-5-6-18-19(13-16)32-14-31-18)28-23(29-21)25-10-7-24(8-11-25,9-12-25)22(26)30/h2-6,13H,7-12,14H2,1H3,(H2,26,30)(H,28,29)
InChi Key
JUHTXZGCTPDXRU-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-34061-1 |
|---|---|
| Supplier Part Number | 34061-1 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | China |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 614749-78-9 |
| Energy Star | No |
| Green | No |
| Controlled | N |