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Cayman ZL006
List Price $602.00 Your Price $602.00
Cayman ZL006 - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART: CAYM-34147-50
MFG.PART: 34147-50
UNSPSC: 12352200
Manufacturer: Cayman
Product Description
ZL006 is an inhibitor of the protein-protein interaction between neuronal nitric oxide synthase (nNOS) and postsynaptic density protein-95 (PSD-95).1 It inhibits NMDA-induced lactate dehydrogenase release (IC50 = 0.082 µM), as well as glutamate and glycine-induced, NMDA receptor-dependent production of nitric oxide (NO), in primary mouse neurons. ZL006 (1.5 mg/kg) prevents ischemia-induced increases in nNOS-PSD-95 complex formation in cortices isolated from a mouse model of ischemia-reperfusion injury induced by middle cerebral artery occlusion (MCAO). It reduces infarct size and increases survival in the same model. ZL006 suppresses mechanical and cold allodynia in a mouse model of neuropathic pain induced by paclitaxel (Item No. 10461).2
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
4-[[(3,5-
CAS Number
1181226-02-7
Molecular Formula
C14H11Cl2NO4
Formula Weight
328.2
Purity
≥98%
Formulation(Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
- DMF: 30 mg/mL
- DMSO: 30 mg/mL
- DMSO:PBS (pH 7.2) (1:3): 0.25 mg/mL
- Ethanol: 10 mg/mL
λmax
310 nm
SMILES
O=C(C1=CC=C(NCC2=C(O)C(Cl)=CC(Cl)=C2)C=C1O)O
InChi Code
InChI=1S/C14H11Cl2NO4/c15-8-3-7(13(19)11(16)4-8)6-17-9-1-2-10(14(20)21)12(18)5-9/h1-5,17-19H,6H2,(H,20,21)
InChi Key
RTEYSQSXRFVKTJ-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-34147-50 |
|---|---|
| Supplier Part Number | 34147-50 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | China |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | Y |
| CAS Number | 1181226-02-7 |
| Energy Star | No |
| Green | No |
| Controlled | N |