Cayman GKT136901

GKT136901 is a dual inhibitor of NADPH oxidase 1 (NOX1) and NOX4 (K_is = 160 and 165 nM, respectively).¹ It is selective for NOX1 and NOX4 over NOX2 and xanthine oxidase (K_is = 1,530 and >30,000 nM, respectively), as well as over a panel of 18 enzymes and ion channels at 10 µM. GKT136901 (0.1, 1, and 10 µM) scavenges peroxynitrite radicals, as well as prevents the nitration and dimerization of α-synuclein, in cell-free assays.² It prevents peroxynitrite-induced cell death of differentiated LUHMES cells when used at a concentration of 10 µM.

WARNING This product is not for human or veterinary use.