Cayman BL 918

BL 918 is an activator of unc-51-like autophagy activating kinase 1 (ULK1).¹ It activates ULK1 with an EC₅₀ value of 24.14 nM in an ADP-based kinase assay. BL 918 (5 µM) increases the levels of ULK1 phosphorylated at serine 317 (Ser³¹⁷) or Ser⁵⁵⁵, reduces the level of ULK1 phosphorylated at Ser⁷⁵⁷, and induces autophagy in SH-SY5Y cells. It reduces motor dysfunction and increases the number of dopaminergic neurons in the striatum in a mouse model of Parkinson’s disease induced by MPTP when administered at doses of 40 and 80 mg/kg.

WARNING This product is not for human or veterinary use.