Cayman 2-deoxy-D-Glucose-13C6

2-deoxy-D-Glucose-¹³C₆ is intended for use as an internal standard for the quantification of 2-deoxy-D-glucose (Item No. 14325) by GC- or LC-MS. 2-deoxy-D-Glucose is a glucose antimetabolite and an inhibitor of glycolysis.^1,2 It inhibits hexokinase, the enzyme that converts glucose to glucose-6-phosphate, as well as phosphoglucose isomerase, the enzyme that converts glucose-6-phosphate to fructose-6-phosphate.³ 2-deoxy-D-Glucose (16 mm) induces apoptosis in SK-BR-3 cells, as well as inhibits the growth of 143B osteosarcoma cells cultured under hypoxic conditions when used at a concentration of 2 mg/mL.^4,5 In vivo, 2-deoxy-D-glucose (500 mg/kg) reduces tumor growth in 143B osteosarcoma and MV522 non-small cell lung cancer mouse xenograft models when used alone or in combination with doxorubicin (Item No. 15007) or paclitaxel (Item No. 10461).⁶

WARNING This product is not for human or veterinary use.