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Cayman Compstatin (trifluoroacetate salt)
List Price
$53.00
Your Price
$53.00
Cayman Compstatin (trifluoroacetate salt) - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART:
CAYM-34435-1
MFG.PART:
34435-1
UNSPSC:
12352200
Manufacturer:
Cayman
Product Description
Compstatin is a cyclic peptide inhibitor of complement activation (IC50s = 63 and 12 µM for the classical and alternative pathways, respectively).1,2 It binds to complement component 3 (C3) and inhibits convertase-mediated cleavage of C3 to the complement activation products C3a and C3b.3 Compstatin (70 µM) inhibits the generation of C3a, activation of polymorphonuclear leukocytes (PMNs), and the binding of PMNs to the polymer surface in an isolated human whole blood model of extracorporeal circulation.4 In vivo, compstatin (21 mg/kg) inhibits the generation of C3b, C3c, and iC3b in a baboon model of heparin- and protamine-induced complement activation.5
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
L-isoleucyl-L-
Synonyms
- ICVVQDWGHHRCT
Molecular Formula
C66H99N23O17S2 • XCF3COOH
Formula Weight
1550.8
Purity
≥98%
Formulation(Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
- DMF: 5 mg/mL
- DMSO: 10 mg/mL
- Ethanol: slightly soluble
- PBS (pH 7.2): 10 mg/mL
λmax
220 nm
SMILES
O=C([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](CSSC[C@H](NC([C@@H](NC([C@@H](NC([C@@H](NC(CNC1=O)=O)CC2=CN=CN2)=O)CC3=CN=CN3)=O)CCCNC(N)=N)=O)C(N[C@H]([C@@H](C)O)C(N)=O)=O)NC([C@@H](N)[C@@H](C)CC)=O)=O)C(C)C)=O)C(C)C)=O)CCC(N)=O)=O)CC(O)=O)N[C@H]1CC4=CNC5=CC=CC=C45.OC(C(F)(F)F)=O
InChi Code
InChI=1S/C66H99N23O17S2.C2HF3O2/c1-8-32(6)50(68)63(104)86-46-27-108-107-26-45(62(103)89-53(33(7)90)54(69)95)85-56(97)39(14-11-17-74-66(70)71)80-59(100)43(20-36-24-73-29-78-36)83-58(99)42(19-35-23-72-28-77-35)79-48(92)25-76-55(96)41(18-34-22-75-38-13-10-9-12-37(34)38)82-60(101)44(21-49(93)94)84-57(98)40(15-16-47(67)91)81-64(105)51(30(2)3)88-65(106)52(31(4)5)87-61(46)102;3-2(4,5)1(6)7/h9-10,12-13,22-24,28-33,39-46,50-53,75,90H,8,11,14-21,25-27,68H2,1-7H3,(H2,67,91)(H2,69,95)(H,72,77)(H,73,78)(H,76,96)(H,79,92)(H,80,100)(H,81,105)(H,82,101)(H,83,99)(H,84,98)(H,85,97)(H,86,104)(H,87,102)(H,88,106)(H,89,103)(H,93,94)(H4,70,71,74);(H,6,7)/t32-,33+,39-,40-,41-,42-,43-,44-,45-,46-,50-,51-,52-,53+;/m0./s1
InChi Key
DURMUHTUCAQKNL-CJVVNLCASA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-34435-1 |
|---|---|
| Supplier Part Number | 34435-1 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | China |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| Energy Star | No |
| Green | No |
| Controlled | N |