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Cayman CCS-1477
List Price
$54.00
Your Price
$54.00
Cayman CCS-1477 - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART:
CAYM-34546-1
MFG.PART:
34546-1
UNSPSC:
12352200
Manufacturer:
Cayman
Product Description
CCS-1477 is an inhibitor of p300 and CREB-binding protein (CBP) histone acetyltransferases.1 It selectively binds to p300 and CBP over bromodomain-containing protein 4 (BRD4; Kds = 1.3, 1.7, and 222 nM, respectively). CCS-1477 inhibits the proliferation of OPM-2 multiple myeloma cells (GI50 = 5 nM). It induces tumor regression in MOLM-16 acute myeloid leukemia (AML) and OPM-2 mouse xenograft models when administered at a dose of 20 mg/kg.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
(6S)-1-(3,4-
CAS Number
2222941-37-7
Synonyms
- CBP-IN-1
Molecular Formula
C30H32F2N4O3
Formula Weight
534.6
Purity
≥98%
Formulation(Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
- DMF: 30 mg/mL
- DMSO: 30 mg/mL
- DMSO:PBS (pH 7.2) (1:3): 0.25 mg/mL
- Ethanol: 10 mg/mL
SMILES
O=C1N(C2=CC(F)=C(C=C2)F)[C@](CCC1)([H])C3=NC4=CC(C5=C(C)ON=C5C)=CC=C4N3[C@]6([H])CC[C@H](CC6)OC
InChi Code
InChI=1S/C30H32F2N4O3/c1-17-29(18(2)39-34-17)19-7-14-26-25(15-19)33-30(36(26)20-8-11-22(38-3)12-9-20)27-5-4-6-28(37)35(27)21-10-13-23(31)24(32)16-21/h7,10,13-16,20,22,27H,4-6,8-9,11-12H2,1-3H3/t20-,22-,27-/m0/s1
InChi Key
SKDNDJWEBPQKCS-CLHVYKLBSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-34546-1 |
|---|---|
| Supplier Part Number | 34546-1 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | China |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | Y |
| CAS Number | 2222941-37-7 |
| Energy Star | No |
| Green | No |
| Controlled | N |