Cayman Tocofersolan

Tocofersolan is a nonionic surfactant and derivative of vitamin E.¹ It has a critical micelle concentration (CMC) of 0.02 mm at room temperature. Tocofersolan inhibits P-glycoprotein (P-gp), also known as multidrug resistance protein 1 (MDR1), substrate-induced ATPase activity in cell-free assays (IC₅₀s = 0.4-3.25 µM).² It reverses locomotor deficits induced by the polycyclic aromatic hydrocarbon benzo[a]pyrene in zebrafish larvae when used at a concentration of 1 µM.³ Intravenous administration of nanocrystals containing tocofersolan (50 mg/kg) and paclitaxel (Item No. 10461) reduces tumor growth in an NCI/ADR-RES ovarian cancer mouse xenograft model.⁴ Liposomes containing tocofersolan and DOTMA (Item No. 25926) and encapsulating anti-miR-21 accumulate in the liver, lung, and spleen and decrease lung fibrosis in a mouse model of pulmonary fibrosis induced by the glycopeptide antitumor antibiotic bleomycin (Item No. 13877).⁵

WARNING This product is not for human or veterinary use.