Cayman Sh-42, 1mg

SH-42 is an inhibitor of ∆²⁴-dehydrocholesterol reductase (DHCR24; IC₅₀ = 4.2 nM).¹ It increases serum levels of desmosterol (24-dehydro cholesterol; Item No. 14943), the immediate precursor of cholesterol (Item No. 9003100) in the Bloch pathway, in mice when administered at a dose of 0.5 mg/animal per day. SH-42 increases levels of arachidonic acid (Item Nos. 90010 | 90010.1 | 10006607) and its metabolite prostaglandin E₂ (PGE₂; Item No. 14010), as well as docosahexaenoic acid (Item No. 90310) and its metabolites 19,20-EpDPA and 19,20-DiHDPA, in the peritoneal lavage fluid in a mouse model of peritonitis induced by zymosan A (Item No. 21175).² SH-42 (0.5 mg/animal three times per week) decreases disease severity in mice expressing liver X receptor α (LXRα-positive) but not LXRα-deficient mice in a model of hepatic steatosis induced by a high-fat high-cholesterol diet.³

WARNING This product is not for human or veterinary use.