Cayman (E/Z)-Capsaicin-d3

Capsaicin-d₃ is intended for use as an internal standard for the quantification of capsaicin (Item Nos. 92350 | 10010743) by GC- or LC-MS. Capsaicin is a terpene alkaloid that has been found in Capsicum and has diverse biological activities.^1,2,3,4 It induces inward currents in HEK293 cells expressing rat transient receptor potential vanilloid 1 (TRPV1; EC₅₀ = 0.64 µM at neutral pH), an effect that can be blocked by the TRPV1 inhibitor A-425619.¹ Capsaicin (10 and 50 µM) decreases LPS-induced prostaglandin E₂ (PGE₂; Item No. 14010) production, as well as reduces LPS- and IFN-induced nitric oxide (NO) release in isolated mouse peritoneal macrophages.² Capsaicin induces substance P (Item No. 24035) release in rat spinal cord slices with an EC₅₀ value of 2.3 µM.³ It reduces acetylcholine- or phenylquinone-induced writhing (ED₅₀s = 1.33 and 1.38 mg/kg, respectively, s.c.) but has no effect on the latency to paw withdrawal in the hot plate test in mice (ED₅₀ = >20 mg/kg, s.c.).⁴ Formulations containing capsaicin have been used in the treatment of nerve pain associated with shingles.

WARNING This product is not for human or veterinary use.