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Cayman 15(R)-HETE
List Price $294.00 Your Price $294.00
Cayman 15(R)-HETE - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART: CAYM-34710-50
MFG.PART: 34710-50
UNSPSC: 12352200
Manufacturer: Cayman
Product Description
15(R)-HETE is a monohydroxy fatty acid. It is produced by aspirin-acetylated COX-2 from arachidonic acid (Item Nos. 90010 | 90010.1 | 10006607) and converted into the specialized pro-resolving mediator 15(R)-lipoxin A4 (Item No. 90415) and 15(R)-lipoxin B4 in a transcellular process via 5-lipoxygenase (5-LO).1,2,3,4,5 It is also produced by the cytochrome P450 (CYP) isoform CYP2C9.1,2,3,6 15(R)-HETE can also be formed from arachidonic acid by COX-1 in stimulated human mast cells and accumulates because, unlike 15(S)-HETE (Item No. 34720), it is not converted to 15-KETE (15-OxoETE; Item No. 34730) by 15-hydroxyprostaglandin dehydrogenase (15-PGDH).7 It is an agonist of PPARβ/δ, inducing expression of a PPARβ/δ target gene in a reporter assay using NIH3T3 cells.8
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
15R-
CAS Number
83603-31-0
Synonyms
- 15(R)-Hydroxyeicosatetraenoic Acid
Molecular Formula
C20H32O3
Formula Weight
320.5
Purity
≥98%
Formulation(Request formulation change)
A solution in ethanol
Solubility(Learn about Variance in Solubility)
- 0.1 M Na2CO3: 2 mg/mL
- DMF: Miscible
- DMSO: Miscible
- Ethanol: Miscible
- PBS pH 7.2: 0.8 mg/mL
λmax
236 nm
SMILES
CCCCC[C@@H](O)\C=C\C=C\C/C=C\C/C=C\CCCC(=O)O
InChi Code
InChI=1S/C20H32O3/c1-2-3-13-16-19(21)17-14-11-9-7-5-4-6-8-10-12-15-18-20(22)23/h4-5,8-11,14,17,19,21H,2-3,6-7,12-13,15-16,18H2,1H3,(H,22,23)/b5-4-,10-8-,11-9-,17-14+/t19-/m1/s1
InChi Key
JSFATNQSLKRBCI-UDQWCNDOSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
Stability
≥ 2 years
| SKU | CAYM-34710-50 |
|---|---|
| Supplier Part Number | 34710-50 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | United States |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | Y |
| CAS Number | 83603-31-0 |
| Energy Star | No |
| Green | No |
| Controlled | N |