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Cayman Tepoxalin
List Price $41.00 Your Price $41.00
Cayman Tepoxalin - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART: CAYM-34849-1
MFG.PART: 34849-1
UNSPSC: 12352200
Manufacturer: Cayman
Product Description
Tepoxalin is a dual inhibitor of COX and 5-lipoxygenase (5-LO; IC50s = 2.84 and 0.15 µM, respectively, in RBL-1 cell lysates).1 It also inhibits the activity of 12-, but not 15-, LO (IC50s = 4.45 and 146.6 µM for the human platelet and rabbit reticulocyte enzymes, respectively). Tepoxalin reduces the production of thromboxane B2 (TXB2; Item No. 19030) and leukotriene B4 (LTB4; Item No. 20110) induced by the calcium ionophore A23187 (Item Nos. 11016 | 22030) in human peripheral blood mononuclear cells (PBMCs; IC50s = 0.01 and 0.07 µM, respectively) and decreases epinephrine-induced platelet aggregation in human platelet-rich plasma (PRP; IC50 = 0.045 µM). It inhibits paw swelling in a rat model of adjuvant-induced arthritis with an ED50 value of 3.5 mg/kg.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
5-(4-chloro
CAS Number
103475-41-8
Synonyms
- ORF 20485
- RWJ 20485
Molecular Formula
C20H20ClN3O3
Formula Weight
385.8
Purity
≥98%
Formulation(Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
- DMF: 30 mg/mL
- DMSO: 30 mg/mL
- Ethanol: 15 mg/mL
- PBS (pH 7.2): insolu
λmax
237, 256 nm
SMILES
ClC(C=C1)=CC=C1C2=CC(CCC(N(O)C)=O)=NN2C3=CC=C(OC)C=C3
InChi Code
InChI=1S/C20H20ClN3O3/c1-23(26)20(25)12-7-16-13-19(14-3-5-15(21)6-4-14)24(22-16)17-8-10-18(27-2)11-9-17/h3-6,8-11,13,26H,7,12H2,1-2H3
InChi Key
XYKWNRUXCOIMFZ-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-34849-1 |
|---|---|
| Supplier Part Number | 34849-1 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | China |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 103475-41-8 |
| Energy Star | No |
| Green | No |
| Controlled | N |