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Cayman Y-33075
List Price $725.00 Your Price $725.00
Cayman Y-33075 - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART: CAYM-35108-10
MFG.PART: 35108-10
UNSPSC: 12352200
Manufacturer: Cayman
Product Description
Y-33075 is an inhibitor of Rho-associated kinase 2 (ROCK2; IC50 = 3.6 nM).1 It is selective for ROCK2 over PKC and calcium/calmodulin-dependent protein kinase II (CaMKII; IC50s = 420 and 810 nM, respectively). Topical application of Y-33075 (0.05% v/v) reduces intraocular pressure in rabbit and cynomolgus monkeys. Y-33075 (10 and 100 µM) increases axonal regeneration at the crush site in a cat model of surgically-induced optic nerve damage.2 It also inhibits demyelination and reduces the incidence of relapse episodes in a mouse model of chronic relapsing experimental autoimmune encephalomyelitis (EAE).3
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
4-[(1R)-1-
CAS Number
199433-58-4
Synonyms
- RKI-983
- SNJ-1656
- Y-39983
Molecular Formula
C16H16N4O
Formula Weight
280.3
Purity
≥98%
Formulation(Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
- DMSO: soluble
SMILES
O=C(C1=CC=C(C=C1)[C@H](N)C)NC2=C3C(NC=C3)=NC=C2
InChi Code
InChI=1S/C16H16N4O/c1-10(17)11-2-4-12(5-3-11)16(21)20-14-7-9-19-15-13(14)6-8-18-15/h2-10H,17H2,1H3,(H2,18,19,20,21)/t10-/m1/s1
InChi Key
JTVBXQAYBIJXRP-SNVBAGLBSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-35108-10 |
|---|---|
| Supplier Part Number | 35108-10 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | United States |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 199433-58-4 |
| Energy Star | No |
| Green | No |
| Controlled | N |