Cayman 3,4-Dihydroxyflavone

3,4-Dihydroxyflavone is a synthetic flavonoid that has diverse biological activities.^1,2,3,4 It inhibits tankyrase 1 (TNKS1) and TNKS2 (IC₅₀s = 0.23 and 0.17 µM for the human enzymes, respectively).¹ 3,4-Dihydroxyflavone is active against L. donovani, T. brucei, and T. cruzi with IC₅₀ values of 2, 1.1, and 10.1 µg/mL, respectively.² It induces apoptosis in and inhibits migration of GL15 glioblastoma cells when used at a concentration of 50 µM.³ 3,4-Dihydroxyflavone (5 mg/kg) prevents LPS-induced increases in brain levels of COX-2 and inducible nitric oxide synthase (iNOS) in a mouse model of neuroinflammation.⁴

WARNING This product is not for human or veterinary use.