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Cayman Odevixibat
List Price $520.00 Your Price $520.00
Cayman Odevixibat - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART: CAYM-35344-25
MFG.PART: 35344-25
UNSPSC: 12352200
Manufacturer: Cayman
Product Description
Odevixibat is an inhibitor of the sodium/bile acid and sulfated solute cotransporter (ASBT; IC50 = 0.16 nM).1 It inhibits intestinal reabsorption of [75Se]homotaurocholic acid (75SeHCAT) by 74% in ApoE-/- mice when administered at a dose of 0.156 µmol/kg. Formulations containing odevixibat have been used in the treatment of pruritis in patients with progressive familial intrahepatic cholestasis, an inborn error of metabolism characterized by mutations in various genes involved in bile production and transport, including ATP8B1 and ABCB11.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
(2S)-2-[[(2R)-2-[[2-[[3,3-dibutyl-2,3,4,5-tetrahydro-7-(methylthio)-1,1-dioxido-5-phenyl-1,2,5-benzothiadiazepin-8-yl]oxy]acetyl]amino]-2-(4-hydroxyphenyl)acetyl]amino]-butanoic acid
CAS Number
501692-44-0
Synonyms
- A4250
Molecular Formula
C37H48N4O8S2
Formula Weight
740.9
Purity
≥90%
Formulation(Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
- DMSO: Soluble
λmax
223, 281 nm
SMILES
O=S1(C2=CC(OCC(N[C@H](C3=CC=C(C=C3)O)C(N[C@@H](CC)C(O)=O)=O)=O)=C(SC)C=C2N(C4=CC=CC=C4)CC(CCCC)(N1)CCCC)=O
InChi Code
InChI=1S/C37H48N4O8S2/c1-5-8-19-37(20-9-6-2)24-41(26-13-11-10-12-14-26)29-21-31(50-4)30(22-32(29)51(47,48)40-37)49-23-33(43)39-34(25-15-17-27(42)18-16-25)35(44)38-28(7-3)36(45)46/h10-18,21-22,28,34,40,42H,5-9,19-20,23-24H2,1-4H3,(H,38,44)(H,39,43)(H,45,46)/t28-,34+/m0/s1
InChi Key
XULSCZPZVQIMFM-IPZQJPLYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-35344-25 |
|---|---|
| Supplier Part Number | 35344-25 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 501692-44-0 |
| Energy Star | No |
| Green | No |
| Controlled | N |