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Cayman GPX4 Inhibitor 26a
List Price $62.00 Your Price $62.00
Cayman GPX4 Inhibitor 26a - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART: CAYM-35408-1
MFG.PART: 35408-1
UNSPSC: 12352200
Manufacturer: Cayman
Product Description
GPX4 inhibitor 26a is an inhibitor of glutathione peroxidase 4 (GPX4).1 It inhibits GPX4 activity by 71.7% at 1 µM. GPX4 inhibitor 26a is cytotoxic to 4T1 and MCF-7 breast cancer cells and HT-1080 fibrosarcoma cells (IC50s = 0.78, 6.9, and 0.15 µM, respectively). It decreases intracellular glutathione (GSH) levels and induces lipid peroxidation and ferroptosis in 4T1 cells when used at a concentration of 5 µM. GPX4 inhibitor 26a (15 and 30 mg/kg) reduces tumor growth in a 4T1 mouse xenograft model.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
α-[(2-chloro
CAS Number
2761004-85-5
Synonyms
- Glutathione Peroxidase 4 Inhibitor 26a
- GPX4-IN-3
- PHGPx Inhibitor 26a
- Phospholipid Hydroperoxide Glutathione Peroxidase Inhibitor 26a
Molecular Formula
C29H24ClN3O3S
Formula Weight
530.0
Purity
≥98%
Formulation(Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
- Chloroform: soluble
λmax
269 nm
SMILES
ClCC(N(C(C1=CSC2=CC=CC=C21)C(NCCC3=CC=CC=C3)=O)C4=CC=C(C5=CN=CO5)C=C4)=O
InChi Code
InChI=1S/C29H24ClN3O3S/c30-16-27(34)33(22-12-10-21(11-13-22)25-17-31-19-36-25)28(24-18-37-26-9-5-4-8-23(24)26)29(35)32-15-14-20-6-2-1-3-7-20/h1-13,17-19,28H,14-16H2,(H,32,35)
InChi Key
ZLCPSXKEQBUXRJ-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-35408-1 |
|---|---|
| Supplier Part Number | 35408-1 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | United States |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 2761004-85-5 |
| Energy Star | No |
| Green | No |
| Controlled | N |