Cayman Cu-GTSM

Cu-GTSM is a copper-containing compound and an analog of Cu-ATSM (Item No. 17122) that has diverse biological activities.^1,2,3,4 It is active against methicillin-sensitive and -resistant S. aureus clinical isolates (IC₅₀s = 0.3-0.6 µM for all).¹ Cu-GTSM inhibits the growth of SK-N-MC neuroepithelioma cells and MRC-5 fibroblasts (IC₅₀s = 0.009 and 0.27 µM, respectively).² It induces the production of reactive oxygen species (ROS) in SK-N-MC cells when used at a concentration of 5 µM. Cu-GTSM (2.5 mg/kg) reduces tumor burden in the transgenic adenocarcinoma of mouse prostate (TRAMP) model but induces weight loss and renal toxicity in the same model.³ Cu-GTSM-containing positron-emitting copper isotopes have been used in PET imaging applications for copper trafficking in the TASTPM transgenic mouse model of Alzheimers disease.⁴

WARNING This product is not for human or veterinary use.