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Cayman SR 57227A (hydrochloride)
List Price $649.00 Your Price $649.00
Cayman SR 57227A (hydrochloride) - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART: CAYM-35499-50
MFG.PART: 35499-50
UNSPSC: 12352200
Manufacturer: Cayman
Product Description
SR 57227A is an agonist of the serotonin (5-HT) receptor subtype 5-HT3.1 It selectively binds 5-HT3 receptors (IC50 = 2.8 nM) over 5-HT1A, 5-HT1B, 5-HT1D, 5-HT2, and 5-HT4 receptors (IC50s = >1,000 nM for all). SR 57227A (20 µM) induces contractions in isolated guinea pig ileum, an effect that can be reversed by the 5-HT3 antagonist tropisetron (Item No. 21240). Intrastriatal administration of SR 57227A (1 µg/animal) induces contralateral turning behavior in mice. It reduces immobility time in the forced swim test in rats (ED50 = 7.6 mg/kg), as well as reduces the number of escape failures in a rat model of learned helplessness and the duration of fighting in a mouse model of isolation-induced aggression.2
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
1-(6-chloro-
CAS Number
77145-61-0
Molecular Formula
C10H14ClN3 • HCl
Formula Weight
248.2
Purity
≥98%
Formulation(Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
- DMF: 1 mg/mL
- DMSO: 10 mg/mL
- Ethanol: Slightly soluble
- PBS (pH 7.2): 1 mg/mL
λmax
253 nm
SMILES
ClC1=NC(N2CCC(CC2)N)=CC=C1.Cl
InChi Code
InChI=1S/C10H14ClN3.ClH/c11-9-2-1-3-10(13-9)14-6-4-8(12)5-7-14;/h1-3,8H,4-7,12H2;1H
InChi Key
FUMINTAAUJUVMP-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-35499-50 |
|---|---|
| Supplier Part Number | 35499-50 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | United States |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | Y |
| CAS Number | 77145-61-0 |
| Energy Star | No |
| Green | No |
| Controlled | N |