We use cookies to make your experience better. To comply with the new e-Privacy directive, we need to ask for your consent to set the cookies. Learn about our cookie policy.
Cayman AF38469
List Price
$74.00
Your Price
$74.00
Cayman AF38469 - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART:
CAYM-35530-1
MFG.PART:
35530-1
UNSPSC:
12352200
Manufacturer:
Cayman
Product Description
AF38469 is an inhibitor of sortilin, also known as the neurotensin-3 receptor (NTS3; IC50 = 330 nM).1 It is selective for sortilin over neurotensin-1 (NTS1), δ-opioid, angiotensin II type 1 (AT1), endothelin A (ETA), and ETB receptors, GPR40, PPARδ, and matrix metalloproteinase-12 (MMP-12), and the prostaglandin E2 (PGE2) receptor subtype EP1. AF38469 (400 nM) inhibits the epithelial-to-mesenchymal transition (EMT) in, and reduces migration and invasion of, U87 and A172 glioblastoma cells.2 It also reduces tumor growth in a glioblastoma multiforme mouse xenograft model when administered at a dose of 0.01 g/kg per day.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
2-[[(6-methyl-
CAS Number
1531634-31-7
Molecular Formula
C15H11F3N2O3
Formula Weight
324.3
Purity
≥98%
Formulation(Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
- DMSO: Soluble
- Ethanol: Soluble
λmax
283 nm
SMILES
O=C(C1=C(C(NC2=CC=CC(C)=N2)=O)C=CC(C(F)(F)F)=C1)O
InChi Code
InChI=1S/C15H11F3N2O3/c1-8-3-2-4-12(19-8)20-13(21)10-6-5-9(15(16,17)18)7-11(10)14(22)23/h2-7H,1H3,(H,22,23)(H,19,20,21)
InChi Key
JWCUSQCZMQIBMR-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-35530-1 |
|---|---|
| Supplier Part Number | 35530-1 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | China |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 1531634-31-7 |
| Energy Star | No |
| Green | No |
| Controlled | N |