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Cayman Indium (Iii) Thiosemicarbazone 5b, Size1 Mg, Purity≥
List Price
$32.00
Your Price
$32.00
Cayman Indium (Iii) Thiosemicarbazone 5b, Size - 1 Mg, Purity - ≥95% - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART:
CAYM-35601-1
MFG.PART:
35601-1
UNSPSC:
12352200
Manufacturer:
Cayman
Product Description
Indium (III) thiosemicarbazone 5b is an anticancer agent.1 It is cytotoxic to A549, MCF-7 breast, MCF-7/DDP cisplatin-resistant breast, and Hl 7702 liver cancer cells (IC50s = 2.41, 1.97, 2.11, and 8.95 µM, respectively). Indium (III) thiosemicarbazone 5b decreases PI3K, Akt, mTOR, P-gp, and GSH levels in MCF-7/DDP cells. In vivo, indium (III) thiosemicarbazone 5b (2.5 µmol/kg) reduces tumor weight and volume in an MCF-7/DDP mouse xenograft model. Liposomes containing indium (III) thiosemicarbazone 5b also induce apoptosis and pro-death autophagy in MCF-7/DDP cells, as well as reduce tumor volume and weight in an MCF-7/DDP mouse xenograft model.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
(OC-6-43)-
CAS Number
2345755-20-4
Molecular Formula
C10H15Cl2InN4OS
Formula Weight
425.0
Purity
≥95%
Formulation(Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
- DMF: 10 mg/mL
- DMF:PBS (pH 7.2) (1:2): 0.30 mg/mL
- DMSO: 1 mg/mL
- Ethanol: Slightly Soluble
λmax
302, 411 nm
SMILES
[Cl-][In+3]12([O-]C)([S]=C([N](C)C)[NH][N]1=CC3=CC=CC=[N]32)[Cl-]
InChi Code
InChI=1S/C9H12N4S.CH3O.2ClH.In/c1-13(2)9(14)12-11-7-8-5-3-4-6-10-8;1-2;;;/h3-7H,1-2H3,(H,12,14);1H3;2*1H;/q;-1;;;+3/p-2/b11-7+;;;;
InChi Key
VNKHZVLDFDLQKI-UTUIWUMXSA-L
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
Stability
≥ 2 years
| SKU | CAYM-35601-1 |
|---|---|
| Featured | No |
| Supplier Part Number | 35601-1 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Refrigerated |
| CountryOfOrigin | United States |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 2 |
| Hazardous | N |
| CAS Number | 2345755-20-4 |
| Energy Star | No |
| Green | No |
| ACT Ecolabel | No |
| Controlled | N |