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Cayman 8-Chloroadenosine
List Price $36.00 Your Price $36.00
Cayman 8-Chloroadenosine - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART: CAYM-35766-1
MFG.PART: 35766-1
UNSPSC: 12352200
Manufacturer: Cayman
Product Description
8-Chloroadenosine is a nucleoside analog and an active metabolite of the anticancer agent 8-chloro cAMP.1 It is formed from 8-chloro cAMP by phosphodiesterases (PDEs) and upon entry into cells, 8-chloroadenosine is phosphorylated by adenosine kinase to produce 8-chloro-ATP. 8-Chloroadenosine (10 µM) inhibits RNA, but not DNA, synthesis in vitro. It is cytotoxic to patient-derived multiple myeloma cells in a concentration-dependent manner. 8-chloroadenosine (50 mg/kg) reduces tumor growth by 50% in an HCT116 colorectal cancer mouse xenograft model.2
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
8-chloro-
CAS Number
34408-14-5
Molecular Formula
C10H12ClN5O4
Formula Weight
301.7
Purity
≥98%
Formulation(Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
- DMSO: Slightly soluble
λmax
262 nm
SMILES
ClC(N([C@]1([H])O[C@@H]([C@H]([C@H]1O)O)CO)C2=NC=N3)=NC2=C3N
InChi Code
InChI=1S/C10H12ClN5O4/c11-10-15-4-7(12)13-2-14-8(4)16(10)9-6(19)5(18)3(1-17)20-9/h2-3,5-6,9,17-19H,1H2,(H2,12,13,14)/t3-,5-,6-,9-/m1/s1
InChi Key
MHDPPLULTMGBSI-UUOKFMHZSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-35766-1 |
|---|---|
| Supplier Part Number | 35766-1 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | China |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 34408-14-5 |
| Energy Star | No |
| Green | No |
| Controlled | N |