We use cookies to make your experience better. To comply with the new e-Privacy directive, we need to ask for your consent to set the cookies. Learn about our cookie policy.
Cayman PMX-53 (trifluoroacetate salt)
List Price
$359.00
Your Price
$359.00
Cayman PMX-53 (trifluoroacetate salt) - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART:
CAYM-35840-10
MFG.PART:
35840-10
UNSPSC:
12352200
Manufacturer:
Cayman
Product Description
PMX-53 is a macrocyclic complement 5a (C5a) peptidomimetic and an antagonist of the C5a receptor (IC50 = 0.3 µM).1 It inhibits C5a-induced secretion of myeloperoxidase (MPO) in isolated human polymorphonuclear leukocytes (PMNs). PMX-53 (10 mg/kg, p.o.) inhibits vascular leakage, PMN infiltration, and peritoneal TNF-α and IL-6 production in a rat model of the peritoneal Arthus reaction.1 It reduces body weight loss and anorexia and inhibits striatal degeneration in a rat model of Huntington’s disease induced by 3-nitropropionic acid (3-NP; Item No. 14684).2 PMX-53 (3 mg/kg) also reduces atherosclerotic lesion size and lipid content in ApoE-/- mice.3
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
(6→2)-lactam, N-acetyl-L-
CAS Number
514814-99-4
Synonyms
- AcF-[OPdChaWR]
- AcPhe-[Orn-Pro-D-Cyclohexylalanine-Trp-Arg]
- 3D53
Molecular Formula
C47H65N11O7 • XCF3COOH
Formula Weight
896.1
Purity
≥95%
Formulation(Request formulation change)
A solid
Peptide Sequence
AC-Phe[Orn-Pro-D-Cha-Trp-Arg]
Solubility(Learn about Variance in Solubility)
- Water: Soluble
λmax
220 nm
SMILES
O=C([C@H](NC([C@@]1([H])N(CCC1)C([C@H](CCCNC([C@@H](NC2=O)CCCNC(N)=N)=O)NC([C@@H](NC(C)=O)CC3=CC=CC=C3)=O)=O)=O)CC4CCCCC4)N[C@H]2CC5=CNC6=CC=CC=C56.OC(C(F)(F)F)=O
InChi Code
InChI=1S/C47H65N11O7.C2HF3O2/c1-29(59)53-37(25-30-13-4-2-5-14-30)42(61)55-36-20-11-22-50-41(60)35(19-10-23-51-47(48)49)54-44(63)39(27-32-28-52-34-18-9-8-17-33(32)34)56-43(62)38(26-31-15-6-3-7-16-31)57-45(64)40-21-12-24-58(40)46(36)65;3-2(4,5)1(6)7/h2,4-5,8-9,13-14,17-18,28,31,35-40,52H,3,6-7,10-12,15-16,19-27H2,1H3,(H,50,60)(H,53,59)(H,54,63)(H,55,61)(H,56,62)(H,57,64)(H4,48,49,51);(H,6,7)/t35-,36-,37-,38+,39-,40-;/m0./s1
InChi Key
GLBSQYCQCYBLHZ-XRANFBFSSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-35840-10 |
|---|---|
| Supplier Part Number | 35840-10 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 514814-99-4 |
| Energy Star | No |
| Green | No |
| Controlled | N |