Cayman EGFR (Phospho-Tyr1068) Rabbit Monoclonal Antibody (Clone RM443)

Epidermal growth factor receptor (EGFR), also known as HER1 and ErbB-1, is a cell surface receptor and member of the EGF family of receptor tyrosine kinases with roles in cell proliferation, differentiation, and survival.^1,2 It is a transmembrane receptor composed of an intracellular tyrosine kinase domain, a transmembrane lipophilic segment, and an extracellular domain that is expressed in epithelial, mesenchymal, and neuronal tissues.^1,2,3 Under unstimulated conditions, EGFR is an auto-inhibited monomer in the plasma membrane.¹ Upon canonical ligand binding, EGFR undergoes homodimerization or heterodimerization with HER2, HER3, or HER4, which induces a conformational change in the cytoplasmic domain that facilitates autophosphorylation and intracellular signaling. EGFR contains five C-terminal autophosphorylation sites, namely tyrosine 1068 (Tyr¹⁰⁶⁸), Tyr¹¹⁴⁸, Tyr¹¹⁷³, Tyr¹⁰⁸⁶, and Tyr⁹⁹².⁴ EGFR (phospho-Tyr¹⁰⁶⁸) is associated with prolonged progression-free survival in patients with non-small cell lung cancer (NSCLC). Cayman’s EGFR (Phospho-Tyr¹⁰⁶⁸) Rabbit Monoclonal Antibody can be used for Western blot (WB).

WARNING This product is not for human or veterinary use.