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Cayman JPH203 (hydrochloride)
List Price $303.00 Your Price $303.00
Cayman JPH203 (hydrochloride) - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART: CAYM-36053-10
MFG.PART: 36053-10
UNSPSC: 12352200
Manufacturer: Cayman
Product Description
JPH203 is an inhibitor of L-type amino acid transporter 1 (LAT1; IC50 = 0.14 μM for 14C-leucine uptake in S2 cells expressing the human transporter).1 It is selective for LAT1 over LAT2 (IC50 = >10 μM). JPH203 inhibits 14C-leucine uptake by, and growth of, HT-29 cells (IC50s = 0.06 and 4.1 μM, respectively). It induces apoptosis and increases levels of cleaved caspase-3, caspase-7, caspase-9, and poly(ADP-ribose) polymerase (PARP) in YD-38 oral cancer cells when used at a concentration of 3 mm.2 JPH203 (6.3, 12.5, and 25 mg/kg) reduces tumor growth in an HT-29 mouse xenograft model.1
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
O-[(5-amino-2-
CAS Number
1597402-27-1
Synonyms
- KYT-0353
Molecular Formula
C23H19Cl2N3O4 • 2HCl
Formula Weight
545.2
Purity
≥98%
Formulation(Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
- DMF: Slightly soluble
- DMSO: Slightly soluble
- Ethanol: Slightly soluble
SMILES
ClC(C=C(C=C1Cl)C[C@H](N)C(O)=O)=C1OCC2=C3C(N=C(C4=CC=CC=C4)O3)=CC(N)=C2.Cl.Cl
InChi Code
InChI=1S/C23H19Cl2N3O4.2ClH/c24-16-6-12(8-18(27)23(29)30)7-17(25)21(16)31-11-14-9-15(26)10-19-20(14)32-22(28-19)13-4-2-1-3-5-13;;/h1-7,9-10,18H,8,11,26-27H2,(H,29,30);2*1H/t18-;;/m0../s1
InChi Key
MJSAOPNUSNNYQL-NTEVMMBTSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 2 years
| SKU | CAYM-36053-10 |
|---|---|
| Supplier Part Number | 36053-10 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 1597402-27-1 |
| Energy Star | No |
| Green | No |
| Controlled | N |