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Cayman Maytansine
List Price
$927.00
Your Price
$927.00
Cayman Maytansine - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART:
CAYM-36062-10
MFG.PART:
36062-10
UNSPSC:
12352200
Manufacturer:
Cayman
Product Description
Maytansine is an ansa macrolide originally isolated from M. serrata that has anticancer activity.1 It inhibits the growth of L1210, L-5178-Y, and P388 murine leukemia cells (EC50s = 0.6, 12, and 1.5 nM, respectively). Maytansine (20 µM) inhibits erythrocyte and brain tubulin polymerization.2 In vivo, maytansine (0.025-0.1 mg/kg) increases survival in a P388 murine leukemia model.1 It has also been used in the synthesis of cytotoxic payload moieties of antibody-drug conjugates (ADCs).3
WARNING This product is not for human or veterinary use.
Technical Information
CAS Number
35846-53-8
Synonyms
- Maitansine
- NSC 153858
Molecular Formula
C34H46ClN3O10
Formula Weight
692.2
Purity
≥98%
Formulation(Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
- DMF: 1 mg/mL
- DMSO: 10 mg/mL
- Ethanol: 2 mg/mL
- PBS (pH 7.2): insol
λmax
232, 253 nm
SMILES
C[C@]12[C@@]([C@@H]([C@]3([H])C[C@]([C@@H](/C=C/C=C(CC4=CC(N(C(C[C@@H]2OC([C@H](C)N(C)C(C)=O)=O)=O)C)=C(Cl)C(OC)=C4)\C)OC)(NC(O3)=O)O)C)([H])O1
InChi Code
InChI=1S/C34H46ClN3O10/c1-18-11-10-12-26(45-9)34(43)17-25(46-32(42)36-34)19(2)30-33(5,48-30)27(47-31(41)20(3)37(6)21(4)39)16-28(40)38(7)23-14-22(13-18)15-24(44-8)29(23)35/h10-12,14-15,19-20,25-27,30,43H,13,16-17H2,1-9H3,(H,36,42)/b12-10+,18-11+/t19-,20+,25+,26-,27+,30+,33+,34+/m1/s1
InChi Key
WKPWGQKGSOKKOO-RSFHAFMBSA-N
Origin
Synthetic
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-36062-10 |
|---|---|
| Supplier Part Number | 36062-10 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | United States |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 35846-53-8 |
| Energy Star | No |
| Green | No |
| Controlled | N |