Cayman TPX-0022

TPX-0022 is an inhibitor of Src, MET, and CSF-1 receptor tyrosine kinase (FMS) kinases (IC₅₀s = 0.12, 0.14, and 0.76 nM, respectively).¹ It inhibits the proliferation of MKN45 and SNU-5 human gastric cancer cells (IC₅₀s = 0.2 and 0.17 nM, respectively), as well as Ba/F3 pro-B cells expressing TEL-CSF1R (IC₅₀ = 19.3 nM). TPX-0022 (100 nM) inhibits cell migration of HCC827 human lung cancer cells. It inhibits tumor growth in an MKN45 mouse xenograft model when administered at doses of 10 and 30 mg/kg. TPX-0022 (10 mg/kg) also inhibits phosphorylation of MET at Tyr¹²³⁴ and Tyr¹³⁴⁹ in the same model.

WARNING This product is not for human or veterinary use.