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Cayman AG-636
List Price $605.00 Your Price $605.00
Cayman AG-636 - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART: CAYM-36122-25
MFG.PART: 36122-25
UNSPSC: 12352200
Manufacturer: Cayman
Product Description
AG-636 is a dihydroorotate dehydrogenase (DHODH) inhibitor (IC50 = 17 nM).1 It increases levels of ureidosuccinic acid (Item No. 34126) and DHO, pyrimidine biosynthesis metabolites upstream of DHODH, in a panel of six cell lines when used at a concentration of 1 µM. AG-636 (100 mg/kg) induces complete tumor stasis in an OCI-Ly19 diffuse large B cell lymphoma (DLBCL) mouse xenograft model and complete tumor regression in a Z-138 ibrutinib-resistant mantle cell lymphoma mouse xenograft model. It also increases DHO levels and reduces pyrimidine levels in Z-138 and JeKo-1 lymphoma mouse xenograft models.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
1-methyl-5-(2′-
CAS Number
1623416-31-8
Molecular Formula
C21H17N3O2
Formula Weight
343.4
Purity
≥98%
Formulation(Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
- DMSO: soluble
- Water: slightly soluble
λmax
259 nm
SMILES
O=C(C1=CC(C2=CC=C(C3=C(C)C=CC=C3)C=C2)=CC4=C1N(C)N=N4)O
InChi Code
InChI=1S/C21H17N3O2/c1-13-5-3-4-6-17(13)15-9-7-14(8-10-15)16-11-18(21(25)26)20-19(12-16)22-23-24(20)2/h3-12H,1-2H3,(H,25,26)
InChi Key
GSBZRCGZLMBSNY-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-36122-25 |
|---|---|
| Supplier Part Number | 36122-25 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | China |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 1623416-31-8 |
| Energy Star | No |
| Green | No |
| Controlled | N |