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Cayman SEN-12333
List Price
$522.00
Your Price
$522.00
Cayman SEN-12333 - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART:
CAYM-36123-50
MFG.PART:
36123-50
UNSPSC:
12352200
Manufacturer:
Cayman
Product Description
SEN-12333 is an agonist of α7 nicotinic acetylcholine receptors (nAChRs; Ki = 0.26 µM).1 It is selective for α7 nAChRs over α1-, α3-, and α4β2 subunit-containing nAChRs and the serotonin (5-HT) receptor subtype 5-HT3, as well as a panel of 70 additional neurotransmitter, growth factor, and peptide receptors at 10 µM. SEN-12333 activates the α7 nAChR in GH4C1 cells expressing the rat receptor (EC50 = 1.6 µM). Topical application of SEN-12333 prevents decreases in the number of retinal ganglion cells in a rat model of glaucoma in a concentration-dependent manner.2 SEN-12333 (3 mg/kg) reverses scopolamine- or MK-801-induced memory deficits in the novel object recognition test in rats.1
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
N-[4-(3-
CAS Number
874450-44-9
Synonyms
- WAY-317538
Molecular Formula
C20H25N3O2
Formula Weight
339.4
Purity
≥98%
Formulation(Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
- DMF: 5 mg/mL
- DMSO: 5 mg/mL
- Ethanol: 3 mg/mL
- PBS (pH 7.2): insol
λmax
282 nm
SMILES
O=C(CCCCN1CCOCC1)NC2=CC=C(C3=CN=CC=C3)C=C2
InChi Code
InChI=1S/C20H25N3O2/c24-20(5-1-2-11-23-12-14-25-15-13-23)22-19-8-6-17(7-9-19)18-4-3-10-21-16-18/h3-4,6-10,16H,1-2,5,11-15H2,(H,22,24)
InChi Key
XCHIZTUBUXZESJ-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-36123-50 |
|---|---|
| Supplier Part Number | 36123-50 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 874450-44-9 |
| Energy Star | No |
| Green | No |
| Controlled | N |