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Cayman RBN-012759
List Price $267.00 Your Price $267.00
Cayman RBN-012759 - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART: CAYM-36137-5
MFG.PART: 36137-5
UNSPSC: 12352200
Manufacturer: Cayman
Product Description
RBN-012759 is an inhibitor of poly(ADP-ribose) polymerase 14 (PARP14; IC50 = 0.003 µM).1 It is selective for PARP14 over PARP1-4, -5a, -5b, -6-12, -15, and -16 (IC50s = 1->100 µM). RBN-012759 (10 µM) inhibits IFN-γ-induced PARP14 auto-MARylation in CFPAC-1 cells. It inhibits IL-4-induced protumor M2-like macrophage polarization in isolated human primary macrophages. RBN-012759 (1 µM) also induces expression of the genes encoding the pro-inflammatory chemokines chemokine (C-C motif) ligand 13 (CCL13), CCL19, and chemokine (C-X-C motif) ligand 11 (CXCL11) in human kidney cancer tumor explants.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
7-(cyclopropyl
CAS Number
2360851-29-0
Molecular Formula
C19H23FN2O3S
Formula Weight
378.5
Purity
≥98%
Formulation(Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
- DMSO: soluble
λmax
243 nm
SMILES
FC1=C2C(NC(CS[C@@H]3CC[C@H](CC3)O)=NC2=O)=CC(OCC4CC4)=C1
InChi Code
InChI=1S/C19H23FN2O3S/c20-15-7-13(25-9-11-1-2-11)8-16-18(15)19(24)22-17(21-16)10-26-14-5-3-12(23)4-6-14/h7-8,11-12,14,23H,1-6,9-10H2,(H,21,22,24)/t12-,14-
InChi Key
NKZDEFKPZSLQRF-MQMHXKEQSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-36137-5 |
|---|---|
| Supplier Part Number | 36137-5 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | China |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 2360851-29-0 |
| Energy Star | No |
| Green | No |
| Controlled | N |