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Cayman Timosaponin AI
List Price $605.00 Your Price $605.00
Cayman Timosaponin AI - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART: CAYM-36174-25
MFG.PART: 36174-25
UNSPSC: 12352200
Manufacturer: Cayman
Product Description
Timosaponin AI is a steroidal saponin that has been found in A. asphodeloides and has diverse biological activities.1,2,3 It is also a metabolite of timosaponin AIII (Item No. 22236).4 Timosaponin AI inhibits 5-lipoxygenase (5-LO), COX-2, and dipeptidyl peptidase 4 (DPP-4; IC50s = 3.29, 36.43, and 33.25 µM, respectively).1,2 It reduces total cholesterol and triglyceride levels in 3T3-L1 differentiated adipocytes and increases glucose consumption in insulin-resistant BNL CL.2 mouse embryonic liver cells stimulated with insulin.2 Timosaponin AI is cytotoxic to NRK rat kidney epithelial and MOLM-13 acute myeloid leukemia (AML) cells (EC50s = 0.12 and 0.22 mm, respectively).3
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
(3β,5β,25S)-
CAS Number
68422-00-4
Synonyms
- Sarsasapogenin-3-O-β-galactopyranoside
Molecular Formula
C33H54O8
Formula Weight
578.8
Purity
≥98%
Formulation(Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
- DMSO: 10 mm
SMILES
C[C@@]12[C@]3([H])[C@@](C[C@@]1([H])[C@@]4([H])[C@]([C@@]5([C@](C[C@H](CC5)O[C@@H]6O[C@@H]([C@@H]([C@@H]([C@H]6O)O)O)CO)([H])CC4)C)([H])CC2)([H])O[C@]7(CC[C@@H](CO7)C)[C@H]3C
InChi Code
InChI=1S/C33H54O8/c1-17-7-12-33(38-16-17)18(2)26-24(41-33)14-23-21-6-5-19-13-20(8-10-31(19,3)22(21)9-11-32(23,26)4)39-30-29(37)28(36)27(35)25(15-34)40-30/h17-30,34-37H,5-16H2,1-4H3/t17-,18-,19+,20-,21+,22-,23-,24-,25+,26-,27-,28-,29+,30+,31-,32-,33+/m0/s1
InChi Key
ZNEIIZNXGCIAAL-MYNIFUFOSA-N
Origin
Plant/Anemarrhena asphodeloides
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-36174-25 |
|---|---|
| Supplier Part Number | 36174-25 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 68422-00-4 |
| Energy Star | No |
| Green | No |
| Controlled | N |