Cayman DUB-IN-2

DUBs-IN-2 is an inhibitor of ubiquitin-specific protease 8 (USP8; IC₅₀ = 280 nM).¹ It is selective for USP8 over USP7 (IC₅₀ = >100 µM). DUBs-IN-2 increases the level of programmed cell death protein ligand 1 (PD-L1) in H460 cells when used at a concentration of 2 µM and PC-9 cells at 2 and 4 µM.² Intraperitoneal injection of DUBs-IN-2 (1 mg/kg every other day), in combination with an anti-PD-L1 antibody and paclitaxel (Item No. 10461), decreases tumor weight, tumor size, and lung metastasis and increases CD8⁺ T cell numbers within the primary tumor in a 4T1 murine mammary carcinoma model.³

WARNING This product is not for human or veterinary use.