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Cayman CB-103
List Price
$80.00
Your Price
$80.00
Cayman CB-103 - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART:
CAYM-36293-250
MFG.PART:
36293-250
UNSPSC:
12352200
Manufacturer:
Cayman
Product Description
CB-103 is an inhibitor of Notch signaling.1 It binds to the b-trefoil domain (BTD) of recombination signal binding protein for immunoglobulin kappa J region (RBPJ) and inhibits the assembly of the RBPJ-Notch intracellular domain (NICD) transcription complex. CB-103 inhibits ligand-induced Notch signaling in HeLa cells expressing mouse Notch1, -2, -3, or -4 (IC50s = 1.5, 0.9, 1.1, and 2.9 µM, respectively). It reduces expression of the Notch target genes HES1, MYC, and DTX1 in RPMI-8402 T cell acute lymphoblastic leukemia (T-ALL) cells. In vivo, CB-103 (25 mg/kg) reduces tumor volume and increases survival in an HCC-1187 mouse xenograft model.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
6-[4-(1,1-di
CAS Number
218457-67-1
Molecular Formula
C15H18N2O
Formula Weight
242.3
Purity
≥95%
Formulation(Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
- DMF: 11 mg/mL
- DMSO: 5 mg/mL
- Ethanol: 20 mg/mL
- PBS (pH 7.2): 0.25 mg/mL
λmax
245 nm
SMILES
NC1=CC=C(OC2=CC=C(C(C)(C)C)C=C2)N=C1
InChi Code
InChI=1S/C15H18N2O/c1-15(2,3)11-4-7-13(8-5-11)18-14-9-6-12(16)10-17-14/h4-10H,16H2,1-3H3
InChi Key
WHIWGRCYMQLLAO-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-36293-250 |
|---|---|
| Supplier Part Number | 36293-250 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | China |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 218457-67-1 |
| Energy Star | No |
| Green | No |
| Controlled | N |