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Cayman FB23-2
List Price $544.00 Your Price $544.00
Cayman FB23-2 - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART: CAYM-36606-50
MFG.PART: 36606-50
UNSPSC: 12352200
Manufacturer: Cayman
Product Description
FB23-2 is an inhibitor of the mRNA N6-methyladenosine (M6A) demethylase fat mass and obesity-associated (FTO) protein (IC50 = 2.6 µM).1 It reduces the proliferation of NB4 and Mono-Mac-6 cells (IC50s = 0.8 and 1.5 µM, respectively). FB23-2 increases M6A levels in isolated human bone marrow cells, as well as suppresses the proliferation of isolated human bone marrow cells and a panel of acute myeloid leukemia (AML) cells (IC50s = 1.9-5.2 µM). In vivo, FB23-2 (2 mg/kg) delays disease onset and increases survival in a Mono-Mac-6 mouse xenograft model.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
2-[[2,6-di
CAS Number
2243736-45-8
Molecular Formula
C18H15Cl2N3O3
Formula Weight
392.2
Purity
≥98%
Formulation(Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
- DMF: Slightly soluble
- DMSO: Slightly soluble
- Methanol: Slightly soluble
λmax
216 nm
SMILES
O=C(C1=C(NC2=C(C=C(C3=C(C)ON=C3C)C=C2Cl)Cl)C=CC=C1)NO
InChi Code
InChI=1S/C18H15Cl2N3O3/c1-9-16(10(2)26-23-9)11-7-13(19)17(14(20)8-11)21-15-6-4-3-5-12(15)18(24)22-25/h3-8,21,25H,1-2H3,(H,22,24)
InChi Key
ILHNIWOZZKIBNW-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-36606-50 |
|---|---|
| Supplier Part Number | 36606-50 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 2243736-45-8 |
| Energy Star | No |
| Green | No |
| Controlled | N |