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Cayman BO-264
List Price $140.00 Your Price $140.00
Cayman BO-264 - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART: CAYM-36611-10
MFG.PART: 36611-10
UNSPSC: 12352200
Manufacturer: Cayman
Product Description
BO-264 is a transforming acidic coiled-coil containing protein 3 (TACC3) inhibitor.1 It binds to TACC3 in thermal shift and drug affinity responsive target stability (DARTS) assays and inhibits the growth of JIMT-1, HCC1954, MDA-MB-231, MDA-MB-436, and CAL-51 cancer cells (IC50s = 0.19, 0.16, 0.12, 0.13, and 0.36 µM, respectively). BO-264 is cytotoxic to RT4 cells that endogenously express TACC3-FGFR3 fusion proteins (IC50 = 3.66 µM). It induces mitotic arrest, apoptosis, and aberrant spindle formation and reduces centrosomal localization of TACC3 in JIMT-1 cells. BO-264 (25 mg/kg) reduces tumor volume and increases median survival in an EMT6 mouse xenograft model.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
N-[3-(4-meth
CAS Number
2408648-20-2
Molecular Formula
C18H19N5O3
Formula Weight
353.4
Purity
≥98%
Formulation(Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
- DMF: 10 mg/mL
- DMSO: 1 mg/mL
- Ethanol: insol
- PBS (pH 7.2): insol
λmax
252, 312 nm
SMILES
COC(C=C1)=CC=C1C2=NOC(NC3=NC(N4CCOCC4)=NC=C3)=C2
InChi Code
InChI=1S/C18H19N5O3/c1-24-14-4-2-13(3-5-14)15-12-17(26-22-15)20-16-6-7-19-18(21-16)23-8-10-25-11-9-23/h2-7,12H,8-11H2,1H3,(H,19,20,21)
InChi Key
WRCGBYNVBFVRTN-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-36611-10 |
|---|---|
| Supplier Part Number | 36611-10 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 2408648-20-2 |
| Energy Star | No |
| Green | No |
| Controlled | N |