Cayman Miltirone

Miltirone is a tanshinone that has been found in S. miltiorrhiza and has diverse biological activities.^1,2,3,4,5 It protects lard from thermal oxidation when used at a concentration of 0.02%.¹ Miltirone is a partial agonist of the benzodiazepine receptor (IC₅₀ = 0.3 µM).² It inhibits carboxylesterase 2 (CES2; K_i = 0.04 µM) as well as severe acute respiratory syndrome coronavirus (SARS-CoV) main protease (M^pro), also known as 3C-like protease (3CL^pro), and papain-like protease (PL^pro; IC₅₀s = 21.1 and 30 µM, respectively).^3,4 Miltirone is cytotoxic to HCT116 colon cancer cells (IC₅₀ = 4.27 µM) and induces mitochondrial dysfunction and the production of reactive oxygen species (ROS) in the same cells.⁵ In vivo, miltirone (10-60 mg/kg) increases the number of punished crossings in the four-plate test, indicating tranquilizing activity, in mice.²

WARNING This product is not for human or veterinary use.