Cayman CFM 4

CFM 4 is an inhibitor of the protein-protein interaction between anaphase-promoting complex subunit 2 (APC2) and cell cycle and apoptosis regulatory protein 1 (CARP-1).¹ It inhibits the binding of APC2 to CARP-1 (IC₅₀ = 0.75 µM). CFM 4 reduces the proliferation of a variety of breast, prostate, and colon cancer cells in a concentration-dependent manner. It induces cell cycle arrest at the g₀ phase in MDA-MB-468 breast cancer cells and apoptosis in T47D breast cancer cells when used at a concentration of 20 µM. Nanostructure lipid carrier-encapsulated CFM 4 (40 mg/kg every other day) reduces tumor growth in an A549 non-small cell lung cancer (NSCLC) mouse xenograft model.²

WARNING This product is not for human or veterinary use.