Cayman I-Cbp112; 5 Mg; 1640282-31-0; ≥98%

Pifithrin-α (Item No. ) is an inactivator of p53 that blocks p53-dependent transcriptional activation and apoptosis. p-nitro-Pifithrin-α is a cell-permeable analog of pifithrin-α. It blocks p53-mediated expression of p21/WAF1 and apoptosis in cortical neurons ten-fold more potently than pifithrin-α. p-nitro-Pifithrin-α, at 10 µM, suppresses p53-mediated TGF-β1 expression in human proximal tubular cells and attenuates steatosis and liver injury in mice fed a high-fat diet.^, It is slowly converted into a more potent cyclized form, p-nitro cyclic pifithrin-α, when incubated in biological media (t_½ = 8 h).

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