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Cayman YM-155 (chloride)
List Price $304.00 Your Price $304.00
Cayman YM-155 (chloride) - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART: CAYM-36827-50
MFG.PART: 36827-50
UNSPSC: 12352200
Manufacturer: Cayman
Product Description
YM-155 is a survivin inhibitor.1 It inhibits survivin promoter activity in a reporter assay (IC50 = 0.54 nM). YM-155 (10-1,000 nM) reduces survivin levels and induces apoptosis in PC3 and PPC-1 prostate cancer cells. In vivo, YM-155 (3 and 10 mg/kg) inhibits tumor growth, decreases intratumor survivin levels, and induces tumor regression in a PC3 mouse xenograft model. It reduces tumor volume in a MiaPaCa-2 pancreatic cancer mouse xenograft model.2 YM-155 also inhibits severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) papain-like protease (PLpro; IC50 = 2.47 µM) and reduces the number of viral RNA copies in SARS-CoV-2-infected Vero E6 cells.3
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
4,9-dihydro-3-
CAS Number
355406-09-6
Molecular Formula
C20H19N4O3 • Cl
Formula Weight
398.8
Purity
≥98%
Formulation(Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
- DMF: insol
- DMSO: insol
- Ethanol: insol
- PBS (pH 7.2): 5 mg/mL
λmax
245, 252, 272 nm
SMILES
O=C1C2=C(C(C3=C1N(CCOC)C(C)=[N+]3CC4=NC=CN=C4)=O)C=CC=C2.[Cl-]
InChi Code
InChI=1S/C20H19N4O3.ClH/c1-13-23(9-10-27-2)17-18(24(13)12-14-11-21-7-8-22-14)20(26)16-6-4-3-5-15(16)19(17)25;/h3-8,11H,9-10,12H2,1-2H3;1H/q+1;/p-1
InChi Key
NUZWGSASIPTGSA-UHFFFAOYSA-M
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-36827-50 |
|---|---|
| Supplier Part Number | 36827-50 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | China |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 355406-09-6 |
| Energy Star | No |
| Green | No |
| Controlled | N |