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Cayman PPTN (hydrochloride)
List Price
$347.00
Your Price
$347.00
Cayman PPTN (hydrochloride) - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART:
CAYM-36854-10
MFG.PART:
36854-10
UNSPSC:
12352200
Manufacturer:
Cayman
Product Description
PPTN is an antagonist of the purinergic P2Y14 receptor.1 It inhibits forskolin-induced cyclic AMP accumulation in C6 cells expressing human P2Y14 (EC50 = ~10 nM) but not CHO Cells expressing P2Y1, P2Y2, P2Y4, P2Y6, P2Y11, P2Y12, or P2Y13 at 1 µM. PPTN (5 µM) inhibits UDP-glucose-induced IL-1β and chemokine (C-C motif) ligand 2 (CCL2) secretion, as well as ERK, JNK, and p38 MAPK phosphorylation in isolated rat satellite glial cells (SGCs).2 Trigeminal administration of PPTN (5 and 10 µM) reduces mechanical hyperalgesia induced by complete Freund’s adjuvant (CFA) in rats.3
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
4-[4-(4-
CAS Number
1992047-65-0
Molecular Formula
C29H24F3NO2 • HCl
Formula Weight
512.0
Purity
≥98%
Formulation(Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
- DMSO: soluble
- Ethanol: soluble
λmax
268 nm
SMILES
O=C(C1=CC2=CC(C3=CC=C(C(F)(F)F)C=C3)=CC=C2C(C4=CC=C(C5CCNCC5)C=C4)=C1)O.Cl
InChi Code
InChI=1S/C29H24F3NO2.ClH/c30-29(31,32)25-8-5-19(6-9-25)22-7-10-26-23(15-22)16-24(28(34)35)17-27(26)21-3-1-18(2-4-21)20-11-13-33-14-12-20;/h1-10,15-17,20,33H,11-14H2,(H,34,35);1H
InChi Key
FKMVYPCBLWYNAV-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-36854-10 |
|---|---|
| Supplier Part Number | 36854-10 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | United States |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 1992047-65-0 |
| Energy Star | No |
| Green | No |
| Controlled | N |