Cayman Mastoparan X (trifluoroacetate salt)

Mastoparan X is an antimicrobial peptide that has been found in wasp venom.¹ It is active against several Gram-positive and Gram-negative bacteria (MICs = 3-64 and 4-256 µg/mL, respectively) and induces permeabilization of E. coli cytoplasmic membranes by 86% when used at a concentration of 6.4 µg/mL. Mastoparan X induces GDP/GTP exchange by g_i in a concentration-dependent manner and binds to calmodulin (K_d = ^~0.9 nM) in cell-free assays.^2,3 It induces necrosis in T98G glioblastoma multiforme (GBM) cells when used at a concentration of 20 µM.⁴ Mastoparan X (128 µg/mL) induces degranulation of isolated rat peritoneal mast cells and hemolysis of isolated sheep, chicken, and human erythrocytes in a concentration-dependent manner.¹ In vivo, mastoparan X (20 mg/kg) increases survival, decreases disease severity, and prevents damage to jejunal villi and crypts in a mouse model of enterohemorrhagic E. coli infection.⁵

WARNING This product is not for human or veterinary use.