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Cayman AMPR-22 (trifluoroacetate salt)
List Price $735.00 Your Price $735.00
Cayman AMPR-22 (trifluoroacetate salt) - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART: CAYM-36954-50
MFG.PART: 36954-50
UNSPSC: 12352200
Manufacturer: Cayman
Product Description
AMPR-22 is a synthetic antimicrobial peptide derived from the mitochondrial cation channel reactive oxygen species (ROS) modulator 1 (Romo1).1 It is active against S. aureus, methicillin-resistant S. aureus (MRSA), P. aeruginosa, and carbapenem-resistant P. aeruginosa with minimum bactericidal concentration (MBC) values of 2, 2, 2, and 4 µg/mL, respectively. AMPR-22 induces bacterial outer membrane permeability and ATP leakage to the extracellular space in S. aureus and P. aeruginosa in a concentration-dependent manner. It increases survival in a mouse model of sepsis induced by S. aureus when administered at a dose of 10 mg/kg.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
L-lysyl-L-
Synonyms
- KKMMKKGGKFGTFMAIGGIR
Molecular Formula
C98H168N28O22S3 • XCF3COOH
Formula Weight
2186.8
Purity
≥95%
Formulation(Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
- DMF: Slightly soluble
- DMSO: 11 mg/mL
SMILES
OC(C(F)(F)F)=O.O=C(N[C@@H](CCCCN[H])C(N[C@@H](CCSC)C(N[C@@H](CCSC)C(N[C@@H](CCCCN[H])C(N[C@@H](CCCCN[H])C(NCC(NCC(N[C@@H](CCCCN[H])C(N[C@H](C(NCC(N[C@]([C@H](O)C)([H])C(N[C@H](C(N[C@@H](CCSC)C(N[C@H](C(N[C@@](C(NCC(NCC(N[C@@](C(N[C@@H](CCCNC(N)=N)C(O)=O)=O)([H])[C@@H](C)CC)=O)=O)=O)([H])[C@@H](C)CC)=O)C)=O)=O)CC1=CC=CC=C1)=O)=O)=O)CC2=CC=CC=C2)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](CCCCN[H])N[H]
InChi Code
InChI=1S/C98H168N28O22S3.C2HF3O2/c1-10-58(3)80(94(144)112-54-76(129)109-56-78(131)124-81(59(4)11-2)95(145)121-72(97(147)148)38-28-47-107-98(105)106)126-83(133)60(5)113-87(137)69(39-48-149-7)120-93(143)74(52-63-31-16-13-17-32-63)123-96(146)82(61(6)127)125-79(132)57-111-86(136)73(51-62-29-14-12-15-30-62)122-88(138)66(35-20-25-44-101)114-77(130)55-108-75(128)53-110-85(135)65(34-19-24-43-100)116-90(140)68(37-22-27-46-103)117-91(141)70(40-49-150-8)119-92(142)71(41-50-151-9)118-89(139)67(36-21-26-45-102)115-84(134)64(104)33-18-23-42-99;3-2(4,5)1(6)7/h12-17,29-32,58-61,64-74,80-82,127H,10-11,18-28,33-57,99-104H2,1-9H3,(H,108,128)(H,109,129)(H,110,135)(H,111,136)(H,112,144)(H,113,137)(H,114,130)(H,115,134)(H,116,140)(H,117,141)(H,118,139)(H,119,142)(H,120,143)(H,121,145)(H,122,138)(H,123,146)(H,124,131)(H,125,132)(H,126,133)(H,147,148)(H4,105,106,107);(H,6,7)/t58-,59-,60-,61+,64-,65-,66-,67-,68-,69-,70-,71-,72-,73-,74-,80-,81-,82-;/m0./s1
InChi Key
ODSLLZBJJIALDP-JWTDGOCASA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-36954-50 |
|---|---|
| Supplier Part Number | 36954-50 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| Energy Star | No |
| Green | No |
| Controlled | N |