Cayman AcMNPV Major Envelope Glycoprotein Neutralizing Antibody (Clone M001)

Autographa californica multiple nucleopolyhedrovirus (AcMNPV) major envelope glycoprotein is a class III viral fusion protein.¹ AcMNPV is a double-stranded DNA insect virus and member of the Baculoviridae family. AcMNPV major envelope glycoprotein exists as a trimer and is composed of five domains in the low pH, post-fusion state that is highly post-translationally modified via glycosylation sites and a palmitoylation site at the C-terminus.^2,3 It is expressed on the surface of infected cells and budded virions.¹ AcMNPV major envelope glycoprotein is involved in viral envelope-host cell endosome membrane fusion in a low pH-dependent manner and in virion budding.^4,5 Lipoplexes containing AcMNPV major envelope glycoprotein have been used for gene delivery to mammalian cells, which can be inhibited by an AcMNPV major envelope glycoprotein neutralizing antibody.⁶ Cayman’s AcMNPV Major Envelope Glycoprotein Neutralizing Antibody (Clone M001) can be used for microneutralization (MN) assays.

WARNING This product is not for human or veterinary use.