Cayman FcγRI/CD64 Rabbit Monoclonal Antibody (Clone 027)

CD64, also known as high-affinity immunoglobulin γ receptor I (FcγRI), is a transmembrane glycoprotein that binds the Fc region of IgG.¹ It is composed of a ligand-binding α-chain, which contains three extracellular Ig-like domains, a transmembrane region, and a cytoplasmic domain, and two γ-chains, which contain immunoreceptor tyrosine-based activation motifs (ITAMs) that mediate signal transduction.^2,3,4 CD64 is constitutively expressed in myeloid cells, including monocytes and macrophages, but can be induced in neutrophils in response to IFN-γ or g-CSF.^5,3 It is involved in phagocytosis, cytokine release, antibody-dependent cell-mediated cytotoxicity (ADCC), and antigen presentation to primed T cells.^1,6 Mouse CD64 selectively forms immune complexes with IgG2a, whereas human CD64 forms immune complexes with IgG1, IgG3, and IgG4.^1,7 Knockout of Fcgr1, the gene encoding CD64, inhibits clearance of B. pertussis infection in mice.¹ Increased serum levels of CD64 are associated with sepsis.⁸ Cayman’s FcγRI/CD64 Rabbit Monoclonal Antibody (Clone 027) can be used for flow cytometry (FC), immunocytochemistry (ICC), and immunofluorescence (IF) applications.

WARNING This product is not for human or veterinary use.