Cayman FABP6 Rabbit Monoclonal Antibody (Clone 201)

Fatty acid-binding protein 6 (FABP6) is a member of the intracellular lipid-binding protein (iLBP) family with a role in bile acid homeostasis.^1,2 It is composed of 10 antiparallel β-strands, which form a β-barrel containing a lipid binding site and is expressed primarily in enterocytes of the ileum, and to a lesser extent in the adrenal gland, ovaries, and stomach.^3,4,1 FABP6 binds bile acids and fatty acids and interacts with the ileal bile acid transporter to aid in bile acid uptake and facilitate intracellular trafficking of bile acids.¹ Fabp6 knockdown induces dietary fat malabsorption, decreased bile acid reabsorption, and a sex-specific increase in adiposity in mice fed a Western diet.⁵ Serum levels of FABP6 are increased in patients with colorectal cancer and decrease following surgical removal of cancerous tissues.⁶ FABP6^T79M is associated with a decreased risk of type 2 diabetes in obese individuals.⁷ Cayman’s FABP6 Rabbit Monoclonal Antibody (Clone 201) can be used for flow cytometry (FC), immunocytochemistry (ICC), and immunofluorescence (IF) applications.

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