Cayman VE-Cadherin/CD144 Rabbit Monoclonal Antibody (Clone 012)

VE-cadherin, also known as CD144, is a type II classical cadherin and member of the cadherin superfamily of calcium-dependent cell adhesion molecules.¹ It is composed of an N-terminal signal peptide, a pro-peptide, five extracellular cadherin repeats that bind to homotypic cadherins, a transmembrane domain, and a cytoplasmic tail that interacts with the cytoskeleton. VE-cadherin is endothelial cell-specific and is localized to intracellular junctions where it participates in vascular structure assembly.^2,3,4 An anti-VE-cadherin antibody in combination with an anti-CD31 antibody inhibits tube formation in human umbilical vein endothelial cells (HUVECs).⁵ Knockout of Cdh5, the gene encoding VE-cadherin, in mouse embryonic stem cells prevents the formation of vessel-like structures in 11-day-old embryoid bodies.³ VE-cadherin is overexpressed in melanoma and breast cancer and is positively correlated with poor prognosis.⁶ Caymans VE-Cadherin/CD144 Rabbit Monoclonal Antibody (Clone 012) can be used for immunohistochemistry (IHC).

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