Cayman Spla2 (Type Ib) Rabbit Monoclonal Antibody (Clone 004); 50 Μl;

Secretory phospholipase A₂ (sPLA₂) (Type IB) is a calcium-dependent PLA₂ superfamily member that is encoded by PLA2G1B in humans.¹ It is composed of an N-terminal signal peptide, a highly-conserved calcium-binding loop, a catalytic domain, an sPLA₂ Type I-specific disulfide bond that provides stability, and a pancreatic loop. It is primarily expressed in the pancreas but is also expressed in the lung.² Upon activation, sPLA₂ (Type IB) is released into the extracellular space and preferentially hydrolyzes phosphatidylglycerol (PG), phosphatidylcholine (PC), and phosphatidic acid (PA), over phosphatidylserine (PS), phosphatidylethanolamine (PE), and phosphatidylinositol (PI).³ It is involved in lipid nutrient digestion and absorption and also has anthelmintic activity.⁴ Pla2g1b^-/- mice fed a high-fat diet are resistant to obesity and have decreased blood glucose and serum insulin levels and increased fecal lipid levels.⁵ Mutations in PLA2G1B are associated with central adiposity and colorectal cancer.⁴ Cayman’s sPLA₂ (Type IB) Rabbit Monoclonal Antibody (Clone 004) can be used for ELISA.

WARNING This product is not for human or veterinary use.