Cayman Transglutaminase 2 Rabbit Monoclonal Antibody (Clone 013)

Transglutaminase 2 (TG2) is a calcium-dependent enzyme that is involved in a variety of biological activities.^1,2 TG2 is composed of an N-terminal β sandwich containing integrin and fibronectin binding sites, a catalytic domain, a guanine nucleotide-binding site, and two C-terminal β-barrel domains.¹ It is ubiquitously expressed and is localized to the cytosol, cytoskeleton, endoplasmic reticulum, mitochondria, nucleus, cell surface, and extracellular space in a context-dependent manner.³ TG2 catalyzes post-translational modifications of proteins via inter- or intramolecular crosslinking of glutamine and lysine residues or transamidation of glutamine residues with polyamines such as spermidine (Item No. 14918).^1,2 It also exhibits calcium-independent enzyme activities, including GTPase, protein kinase, and disulfide isomerase activities, and binds to several cell surface adhesion molecules in the extracellular matrix (ECM).^1,4 TG2 acts on a wide variety of protein substrates that have roles in neurological, autoimmune, and metabolic diseases, as well as carcinogenesis. Cayman’s Transglutaminase 2 Rabbit Monoclonal Antibody (Clone 013) can be used for ELISA.

WARNING This product is not for human or veterinary use.