Cayman 5-Aminosalicylic Acid-d7

5-Aminosalicylic acid-d₇ (5-ASA-d₇) is intended for use as an internal standard for the quantification of 5-ASA (Item No. 70265) by GC- or LC-MS. 5-ASA is a non-steroidal anti-inflammatory drug (NSAID) and an active metabolite of sulphasalazine (Item No. 15025), basalazide (Item No. 18680), and olsalazine (Item No. 23661).¹ It selectively inhibits COX-2 over COX-1 in isolated human whole blood (IC₅₀s = 61 and 410 µM, respectively). 5-ASA inhibits hemoglobin- and hydrogen peroxide-induced lipid peroxidation in a cell-free assay (IC₅₀ = 50 µM).² It also inhibits the synthesis of leukotriene B₄ (LTB₄; Item No. 20110) in isolated human mucosal cells when used at a concentration of 100 µM.³ Formulations containing 5-ASA have been used in the treatment of inflammatory bowel disease (IBD) and ulcerative colitis.

WARNING This product is not for human or veterinary use.